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One more Hawaii resident died from COVID-19 and two more were hospitalized as the state’s total case count rose to 486 Saturday, according to the Department of Health.

The state reported 21 new COVID-19 cases, including one minor. A total of 44 people with the virus have required hospitalization.

The latest death was a woman over the age of 65 with underlying medical conditions. She tested positive for the virus after being hospitalized on Oahu.

The new cases included 11 that were spread within the community and 10 whose origins were unknown. None were associated with travel, the health department said.

To date, 300 people have been released from isolation, meaning they have not had a fever or muscle pain for 72 hours without the use of medicine.

Of the cases reported Saturday, 14 came from Maui County, where the health department is already investigating several clusters of people who have been infected. It wasn’t clear if the new cases were tied to any of those clusters.

The DOH has been monitoring two clusters at the Maui Memorial Medical Center, where a patient yesterday tested positive for the virus. Eighteen staff have also tested positive at the hospital, where the virus has been identified in a pediatrics ward and another for patients with chronic conditions.

DOH Director Bruce Anderson said Friday that the department is also investigating possible clusters in a church group and among members of a motorcycle club.

Maui County now has 80 cases. Oahu has 348; Hawaii County, 34; and Kauai County, 19.

This weekend, Maui County and Honolulu have implemented nightly driving restrictions. The city has not yet provided data on why the restrictions are necessary to curb spread of the virus.

Honolulu Mayor Kirk Caldwell and Honolulu Police Chief Susan Ballard have previously said they want to prevent large gatherings over the holiday weekend.

Hawaii is already under a stay-at-home order that will last through April 30.